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・ 2-Hydroxy-4-methoxybenzaldehyde
・ 2-Hydroxy-4-methylbenzaldehyde
・ 2-Acetylpyridine
・ 2-Acrylamido-2-methylpropane sulfonic acid
・ 2-acylglycerol O-acyltransferase
・ 2-acylglycerol-3-phosphate O-acyltransferase
・ 2-acylglycerophosphocholine O-acyltransferase
・ 2-alkenal reductase
・ 2-alkyn-1-ol dehydrogenase
・ 2-Amino-1,2-dihydronaphthalene
・ 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
・ 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate synthase
・ 2-Amino-3-carboxymuconic semialdehyde
・ 2-Amino-4-deoxychorismate dehydrogenase
・ 2-Amino-4-deoxychorismate synthase
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase
・ 2-Amino-4-hydroxy-6-pyrophosphoryl-methylpteridine
・ 2-Amino-5-formylamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one
・ 2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase
・ 2-Aminoacridine
・ 2-aminoadipate transaminase
・ 2-aminobenzenesulfonate 2,3-dioxygenase
・ 2-Aminoethoxydiphenyl borate
・ 2-aminoethylphosphonate—pyruvate transaminase
・ 2-aminohexano-6-lactam racemase
・ 2-aminohexanoate transaminase
・ 2-Aminoindane
・ 2-Aminoisobutyric acid
・ 2-aminomuconate deaminase
・ 2-Aminomuconic acid


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2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase : ウィキペディア英語版
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase

In enzymology, a 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase () is an enzyme that catalyzes the chemical reaction
:ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine \rightleftharpoons AMP + (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate
Thus, the two substrates of this enzyme are ATP and 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine, whereas its two products are AMP and (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate.
This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase. Other names in common use include 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, H2-pteridine-CH2OH pyrophosphokinase, 7,8-dihydroxymethylpterin-pyrophosphokinase, HPPK, 7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase, and hydroxymethyldihydropteridine pyrophosphokinase. This enzyme participates in folate biosynthesis.
This enzyme catalyses the first step in a three-step pathway leading to 7,8 dihydrofolate. Bacterial HPPK (gene folK or sulD) is a protein of 160 to 270 amino acids. In the lower eukaryote ''Pneumocystis carinii'', HPPK is the central domain of a multifunctional folate synthesis enzyme (gene fas).
==Structural studies==

As of late 2007, 23 structures have been solved for this class of enzymes, with PDB accession codes , , , , , , , , , , , , , , , , , , , , , , and .

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